To the authors knowledge this is the first single arm phase i ii clinical trial of repeated dose umbilical cord mesenchymal stem cells administration in children diagnosed with autism spectrum disorder asd.
Mesenchymal stem cells and autism.
The primary sources of the msc in clinical trials are bone marrow fat tissue and umbilical cord tissue 24 27.
Due to the particular immune and neural dysregulation observed in asds.
Among the stem cell population mesenchymal stem cells mscs show probably best potential good results in medical research.
Umbilical cord mesenchymal stem cell infusions were safe and generally well tolerated.
In fact one recent study using a mouse strain bred to have autistic like symptoms showed that transplantation of mesenchymal stem cells resulted in a reduction in stereotypical behaviors a decrease in cognitive rigidity and an improvement in social behavior.
Why treat autism with mesenchymal stem stromal cells msc.
Mesenchymal stem cell transplantation for the treatment of autism spectrum disorders is a novel approach that deserves further investigation however substantial methodological and theoretical.