Mesenchymal Stem Cell Exosomes The Future Msc Based Therapy

2013 mesenchymal stem cell exosomes.

Mesenchymal stem cell exosomes the future msc based therapy.

Mesenchymal stem cell msc based therapy is thought to be a promising strategy for pni 19 21. Mesenchymal stem cells mscs have generated enormous interest in the field of regenerative medicine due to their ability to undergo multilineage differentiation their favorable characteristics for culture and manipulation in vitro and their strong immunomodulatory activity mscs regulate t and b cells through the production of immunosuppressive molecules including. Mesenchymal stem cells mscs are multipotent cells that prefer to differentiate into cells of the musculoskeletal system such as bone cartilage muscle and fat cells. Preclinical studies have indicated that the cartilage of the joint can be protected from degeneration and the development of oa can be delayed through intra articular injection of mscs isolated.

Previous studies have shown that transplanted mscs can differentiate into scs an important type of glial cell in the peripheral nerve system that mediates axonal regeneration in vivo providing the support and nutrition needed for axonal growth. Their widespread use stems from their demonstrated potency in a broad range of. Types of mesenchymal stem cell msc therapies. Stem cell biology and regenerative medicine.

In some applications of cell therapy cell types derived from mscs in the laboratory are transplanted into the recipients in combination with biomaterials as tissue engineering te products. Therefore careful attention to detail in producing msc exosomes may provide a new therapeutic paradigm for cell free msc based therapies with decreased risk. Lai and others published mesenchymal stem cell exosomes. Mesenchymal stem stromal cell msc based therapy is a promising new approach for oa which has been further developed in recent years 9 10 11 12 13.

A novel stem cell based therapy for cardiovascular disease r eview stem cell crypt in the intestine 54. Chase l vemuri m. Protect against ischemic renal 49 50 and limb tissue injury 52. There are over 600 clinical trials now listed at www clinicaltrials gov utilizing mscs.

In autologous transplantation mscs can home to injured tissue sites in the body and persist for some time. And support the formation of megakaryocytes and. Pdf on jan 1 2013 r c. In this article dr.

Eds mesenchymal stem cell therapy. Find read and cite all the research you need on researchgate. The future msc based therapy. Mesenchymal stem stromal cells mscs are one of the most commonly employed cell types under investigation as an experimental cell based therapy for treating human diseases.