Mesenchymal Stem Cell Based Therapy For Cartilage Repair A Review

The purpose of this paper is to review the literature on msc based cell therapy for articular cartilage repair to determine if it can be an alternative treatment for cartilage injury.

Mesenchymal stem cell based therapy for cartilage repair a review.

A distinct population of chondrocyte progenitor cells exists in the superficial surface zone of articular cartilage 103 117. Current techniques for cartilage defects repair clinical cartilage repair strategies are required both to prevent the degeneration of cartilage defects into oa and to restore replace the defects. A review article literature review pdf available in knee surgery sports traumatology arthroscopy 17 11 1289 97 april 2009 with. This review describes progress and development of employing mesenchymal stromal cell msc based therapy as a promising alternative for oa treatment.

Mesenchymal stem cell msc transplantation has been introduced to avoid some of the side effects and complications of current techniques. Mesenchymal stem cell based therapy for cartilage repair. Brinchmann æ takeshi muneta æ ichiro sekiya received. Mesenchymal and stromal cells have also been used for equine cell based cartilage repair.

31 march 2009 springer verlag 2009 abstract articular cartilage injury remains one of the major concerns in orthopaedic surgery. 4 march 2009 published online. Mesenchymal stem cells in the treatment of traumatic articular cartilage defects. Mesenchymal stem cell based therapy for cartilage repair.

Mesenchymal stem cells mscs have been in the limelight of cell based therapies to promote cartilage repair. A comprehensive review troy d bornes adetola b adesida and nadr m jomha department of surgery university of alberta laboratory of stem cell biology and orthopaedic tissue engineering edmonton alberta t6g 2e1 canada. However the poor ability of cartilage to self repair has motivated efforts to engineer replacement tissues and human mesenchymal stem cells msc which have an extensive proliferation potential. The emergence of the new discipline of regenerative medicine having cell based therapy as its primary focus may enable us to achieve repair and restore the damaged articular cartilage.

Despite progressive advancements in msc manipulation and the introduction of various bioactive scaffolds and growth factors in preclinical studies current clinical trials are still at early stages with preliminary aims to evaluate safety feasibility and efficacy.